He belongs from a Baloch tribe khosa. He was born in Bahadurgarh, Dera Ghazi Khan, Pakistan. He became the Tumandar and Chief of the Khosa tribe in 1935 after the death of his father, Sirdar Dost Muhammad Khan Khosa. He was the Governor of the Punjab from 17 August 1999 to 21 October 1999. On 26 June 2008, he won the PP-243 seat of the Punjab assembly after defeating the Leghari candidate for the third time.

PML N Sardar Zulfiqar Khosa watching Mujra in Denmark